The role of insulin sensitivity (IS), as well as the association of IS with fibrinolysis impairment, in the occurrence of ischemic stroke, has not been clarified. The study was aimed to analyze IS, plasma insulin (PI) and  plasminogen activator inhibitor (PAI)-1 levels in 34 type 2 diabetics (T2D) with ischemic stroke (group A), 30 T2D without ischemic stroke (group B), 33 nondiabetics with ischemic stroke (group C) and 33 healthy controls (group D). Ischemic stroke was confirmed by clinical and neuroimaging criteria. IS levels were determined by the minimal model analysis (Si index).

Insulin resistance (IR) with resultant hyperinsulinism is basically the origin of the development process from obesity to insulin-independent diabetes mellitus (NIDDM). This process contributes to a reduced physical activity that is manifested in a reduced physical ability. Under the influence of a regular individually measured physical activity of aerobic character, it is possible to increase biological efficiency of insulin and affect the process of early and evolutive atherosclerosis.