A very serious disease, characterized by low bone mass and microarchitectural deterioration of bone tissue with increasing bone fragility enhanced bone and a consequent increase in fracture risk. There are many causes of osteoporosis but the most common by far is due to the decrease in the amount of bone which occurs after the menopause, the so called postmenopausal osteoporosis. In the osteoporotic bone the cortical shell and the trabeculae become thinned, and the architecture of the cancellous bone is destroyed.